Target
Potassium voltage-gated channel, shaker-related subfamily, member 3
Description
Anti-Potassium voltage-gated channel Antibody, Non-Fucosylated (BioBet-1143ZP) is a humanized monoclonal IgG antibody against Potassium voltage-gated channel, shaker-related subfamily, member 3. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Inflammatory Diseases
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Potassium voltage-gated channel, shaker-related subfamily, member 3 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
potassium channel, voltage gated shaker related subfamily A, member 3
Background
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes- shaker, shaw, shab, and shal- have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.
Alternative Names
KCNA3; potassium channel, voltage gated shaker related subfamily A, member 3; MK3; HGK5; HLK3; PCN3; HPCN3; KV1.3; HUKIII; potassium voltage-gated channel subfamily A member 3; potassium channel 3; type n potassium channel; voltage-gated K(+) channel HuKIII; voltage-gated potassium channel protein Kv1.3; voltage-gated potassium channel subunit Kv1.3; potassium voltage-gated channel, shaker-related subfamily, member 3
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with KCNA3 include Alzheimer Disease 17.
Related Pathways
Its related pathways are Potassium Channels and Transmission across Chemical Synapses.
Function
Mediates the voltage-dependent potassium ion permeability of the activated membrane. Assuming that the opening or closing conformation responds to the transmembrane voltage difference, the protein forms a potassium selective channel through which potassium ions can pass through its electrochemical gradient.
Post-translational modifications
1.N-glycosylation promotes the cell surface expression 2.Modification sites at PhosphoSitePlus 3.Glycosylation at Asn279 4.Ubiquitination at Lys120 and Lys526
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1143ZP
Description
The anti-Kv1. 3 sdAbs, something that has historically been difficult to achieve with other drug modalities such as small molecules and peptide-based toxins. The Kv1. 3 ion channel represents an important target in inflammatory disease as it helps control ion influx required for activation of T lymphocytes.
Antibody Indication
Inflammatory Diseases
