Anti-Platelet Activating Factor Antibody, Non-Fucosylated (BioBet-1636ZP) (CAT#: BioBet-1636ZP) Datasheet

PAF

Platelet Activating Factor

PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation and degranulation, inflammation, and anaphylaxis. It is also involved in changes to vascular permeability, the oxidative burst, chemotaxis of leukocytes, as well as augmentation of arachidonic acid metabolism in phagocytes.

PAF; Platelet Activating Factor; PAF-acether; AGEPC; acetyl-glyceryl-ether-phosphorylcholine

Nucleus

Diseases associated with PLA2G7 include Platelet-Activating Factor Acetylhydrolase Deficiency and Ige Responsiveness, Atopic.

Its related pathways are Sweet Taste Signaling and Acyl chain remodelling of PE.

Lipoprotein-related calcium-independent phospholipase A2 participates in the catabolism of phospholipids during inflammation and oxidative stress.At the lipid-water interface, the fatty acyl ester bond (phospholipase A2 activity) is hydrolyzed at the phospholipid Sn-2 position.Phospholipids targeting sn-2 short-chain fatty acid acyl are targeted.Phospholipids with long lipid chains can hydrolyze only if they carry oxidative functional groups.Congestion hydrolysis, lose the activated platelet activating factor - (1 - O - alkyl - 2 - acetyl - sn - glycero - 3 - phosphocholine), a powerful signaling role of proinflammatory lipid through various PTAFR innate immune cells.Hydrolytic oxidative truncated phospholipids with an aldehyde group at the omega location prevent their accumulation in low-density lipoprotein (LDL) particles and uncontrolled proinflammatory effects.As part of high-density lipoprotein (HDL) particles, phospholipids containing long chain fatty acid acylhydroperoxide at the SN-2 site can be hydrolyzed to prevent the potential accumulation of these lipids in the blood vessel wall.Catalyze membrane phospholipids to release F2-isoprostaglandin, a lipid biomarker of cellular oxidative damage.

1.N-glycosylated. Macrophage-derived PLA2G7 carries sialylated complex-type N-glycans that hinder its binding to HDL particles 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1636ZP

Mouse

Human

The antibody bind to Platelet Activating Factor (PAF), and it can be used for the treatment of inflammatory diseases.

Inflammatory Diseases

Inflammatory Diseases