Target
Plasmalemma vesicle-associated protein
Description
Anti-Plasmalemma vesicle-associated protein Antibody, Non-Fucosylated (BioBet-1575ZP) is a human monoclonal IgG antibody against Plasmalemma vesicle-associated protein. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Liver Cancer; Hepatocellular Carcinoma (HCC)
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Plasmalemma vesicle-associated protein antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
plasmalemma vesicle associated protein
Alternative Names
PLVAP; plasmalemma vesicle associated protein; PV1; FELS; PV-1; gp68; plasmalemma vesicle-associated protein; plasmalemma vesicle protein 1; fenestrated endothelial-linked structure protein; fenestrated-endothelial linked structure protein; PV-1 protein;
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with PLVAP include Diarrhea 10, Protein-Losing Enteropathy Type and Congenital Diarrhea 7 With Exudative Enteropathy.
Function
Endothelial cell-specific membrane proteins are involved in the formation of the diaphragm connecting the endothelial pores. It is also necessary for the formation of sacs and transcutaneous passages. The function of capillary permeability, endothelial pores help water and solutes pass, and regulate the flow of extracellular and adjacent cells in different organs. It plays a special role in embryonic development.
Post-translational modifications
1.Glycosylation at Asn83, Asn89, Asn113, and Asn151 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1575ZP
Description
The antibody specifically binds an extracellular domain epitope of a mammalian PLVAP protein. These agents are involved diagnosing and treating hepatocellular carcinoma (HCC).
Antibody Indication
Liver Cancer; Hepatocellular Carcinoma (HCC)
