Description
ADCC-Enhanced anti-Phospholipase D4 (5B7) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Autoimmune Diseases; Tumor
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Phospholipase D4 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
PLD4
Full Name
phospholipase D family, member 4
Alternative Names
PLD4; phospholipase D family, member 4; C14orf175; phospholipase D4; PLD 4; choline phosphatase 4; phosphatidylcholine-hydrolyzing phospholipase D4;
Gene ID
122618
Cellular Localization
Golgi apparatus, Endosome, Nucleus, Endoplasmic reticulum
Involvement in Disease
Diseases associated with PLD4 include Nephrotic Syndrome, Type 7.
Related Pathways
Its related pathways are Acyl chain remodelling of PE and phospholipases.
Function
5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor. Involved in phagocytosis of activated microglia.
Post-translational modifications
1.Highly N-glycosylated 2.Modification sites at PhosphoSitePlus 3.Glycosylation at Asn171, Asn249, Asn281, and Asn417 4.Ubiquitination at Lys271 and Lys276
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
5B7
Description
This is a monoclonal antibodyy that binds to phospholipase D4. And it can be used for autoimmune diseases and tumor.
Antibody Indication
Autoimmune Diseases; Tumor
Autoimmune Diseases; Tumor
