Anti-Phospholipase A2 Antibody, Non-Fucosylated (BioBet-1641ZP) (CAT#: BioBet-1641ZP) Datasheet

PLA2

Phospholipase A2

Phospholipases A2 (PLA2s) are enzymes that release fatty acids from the second carbon group of glycerol. This particular phospholipase specifically recognizes the sn-2 acyl bond of phospholipids and catalytically hydrolyzes the bond releasing arachidonic acid and lysophospholipids.

PLA2; Phospholipase A2; PLA2G1B; PLA2G2A; PLA2G2C; PLA2G2D; PLA2G2E; PLA2G2F; PLA2G3; PLA2G4A; PLA2G4B; PLA2G4C; PLA2G4D; PLA2G4E; PLA2G4F; PLA2G5; PLA2G6; PLA2G7; PLA2G10; PLA2G12A; PLA2G12B

Plasma membrane, Extracellular region or secreted

Diseases associated with PLA2G2A include Colorectal Cancer and Gas Gangrene.

Its related pathways are Sweet Taste Signaling and Acyl chain remodelling of PE.

Secretion of calcium-dependent phospholipase A2 mainly acts on extracellular phospholipids and plays a role in host antibacterial defense, inflammatory response and tissue regeneration. Hydrolysis of the ester bond of the fatty acyl group (phospholipase A2 activity) attached to the sn-2 position of the phospholipid prefers phosphatidylethanolamine and phosphatidylglycerol over phosphatidylcholine. Contribute to lipid remodeling of cell membranes and production of lipid mediators to participate in pathogen clearance. It has bactericidal activity against Gram-positive bacteria by directly hydrolyzing the phospholipids of bacterial membranes. Under aseptic inflammation, the target is the extracellular mitochondrial membrane phospholipids released by activated platelets to generate free unsaturated fatty acids, such as arachidonic acid, which are used by neighboring white blood cells to synthesize inflammatory eicosanoids, such as white three Ene. At the same time, by damaging the integrity of the mitochondrial membrane, it promotes the release of effective damage-related molecular pattern molecules in the circulation and activates the innate immune response. It plays a role in regulating stem cells in the intestinal crypts. In the cell, it mediates the differentiation of Paneth cells and their stem cell support function by inhibiting the Wnt signaling pathway of intestinal stem cells. Secreted in the intestinal lumen during inflammation, autocrine, promote the synthesis of prostaglandin E2, stimulate the Wnt signaling pathway in ICS cells and tissue regeneration (similar). It may be involved in the biosynthesis of n-acylethanolamine, regulating energy metabolism and inflammation. The n-acylphosphatidylethanolamine is hydrolyzed to n-acyl lysophosphatidylethanolamine, which is further cleaved by lysophospholipase D to release n-acylethanolamine. Independent of catalytic activity, as a ligand for integrins. Combines and activates the integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binding to sites (site 2) different from the classic ligand binding site (site 1) induces conformational changes of the integrin and enhances the binding of the ligand to site 1. Induce cell proliferation in an integrin-dependent manner.

The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments, or by alternative splicing, as in the case of isoform 2 that shares all characteristics of secretory phospholipase A2 receptor form (By similarity).

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1641ZP

Human

Human

The antibody directed to the antigen phospholipase A2 (PLA2), can be use for the treatment of inflammatory diseases.

Inflammatory Diseases

Inflammatory Diseases