Anti-PF4 Antibody, Non-Fucosylated (BioBet-1499ZP) (CAT#: BioBet-1499ZP) Datasheet

PF4

PF4; platelet factor 4; PF-4; CXCL4; SCYB4; iroplact; oncostatin-A; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4;

This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum.

Platelet factor 4

Extracellular region or secreted

Diseases associated with PF4 include Intermediate Coronary Syndrome and Erythromelalgia.

Its related pathways are Signaling by GPCR and Cell surface interactions at the vascular wall.

Released when platelets aggregate. Neutralizes the anticoagulant effect of heparin because its binding to heparin is stronger than to the chondroitin sulfate chain of the carrier molecule. Chemotaxis of neutrophils and monocytes. Inhibiting endothelial cell proliferation, the short form is a more effective inhibitor than the long form.

Proteolytic removal of residues 1-9 produces the active peptide connective tissue-activating peptide III (CTAP-III) (low-affinity platelet factor IV (LA-PF4)). Proteolytic removal of residues 1-13 produces the active peptide beta-thromboglobulin, which is released from platelets along with platelet factor 4 and platelet-derived growth factor. NAP-2(1-66) is produced by proteolytical processing, probably after secretion by leukocytes other than neutrophils. NAP-2(73) and NAP-2(74) seem not be produced by proteolytical processing of secreted precursors but are released in an active form from platelets.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1
heavy chains and kappa light chains

BioBet-1499ZP

Mouse

Human

Anti-PF4/heparin antibody that bind to platelet factor 4 (PF4), are used to treat Heparin-induced thrombocytopenia (HIT).

Heparin-induced Thrombocytopenia (HIT)

Heparin-induced Thrombocytopenia (HIT)