Description
Anti-Periostin Antibody, Non-Fucosylated (BioBet-1548ZP) is a mouse monoclonal IgG antibody against Periostin. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Periostin-Related Diseases
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Periostin antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
POSTN
Full Name
Periostin
Background
periostin, osteoblast specific factor
Alternative Names
POSTN; periostin, osteoblast specific factor; PN; OSF2; OSF-2; PDLPOSTN; periostin; periostin; periodontal ligament-specific periostin; osteoblast specific factor 2 (fasciclin I-like);
Gene ID
10631
Cellular Localization
Golgi apparatus, Extracellular region or secreted
Involvement in Disease
Diseases associated with POSTN include Melorheostosis and Myocardial Infarction.
Related Pathways
Its related pathways are Amplification and Expansion of Oncogenic Pathways as Metastatic Traits and Hypothesized Pathways in Pathogenesis of Cardiovascular Disease.
Function
Induce cell attachment and spread, and play a role in cell adhesion. Enhance the binding of BMP1 in the connective tissue fibronectin matrix and subsequent proteolytic activation of lysine oxidase LOX (by similarity).
Field of research
Cancer antibody; Cell Biology and Cellular Response antibody; Controls and Markers antibody; Signaling Transduction antibody
Post-translational modifications
Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; this may be required for calcium binding. According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1548ZP
Description
An antibody is against a periostin isoform having anti-cell adhesive activity, used as therapeutic agent for periostin-related diseases.
Antibody Indication
Periostin-Related Diseases
Periostin-Related Diseases
