Target
Peptidoglycan recognition protein 1
Description
Anti-Peptidoglycan recognition protein 1 Antibody, Non-Fucosylated (BioBet-1545ZP) is a chimeric monoclonal IgG antibody against Peptidoglycan recognition protein 1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Bacterial Infection; Inflammatory Diseases
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Peptidoglycan recognition protein 1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
PGLYRP1; peptidoglycan recognition protein 1; PGRP; TAG7; PGRPS; PGLYRP; PGRP-S; TNFSF3L; TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein);
Alternative Names
peptidoglycan recognition protein 1
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with PGLYRP1 include Spherocytosis, Type 2 and Mite Infestation.
Related Pathways
Its related pathways are Innate Immune System and Defensins.
Function
A model receptor that binds to the murein peptidoglycan (PGN) of gram-positive bacteria. It has bactericidal activity against Gram-positive bacteria. It can kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. It also binds to Gram-negative bacteria and has antibacterial activity against Gram-negative bacteria. Play a role in innate immunity
Field of research
Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody; Microbiology and Infectious Disease antibody; Neuroscience antibody
Post-translational modifications
N-glycosylated. N-glycosylation is required for bactericidal activity
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1545ZP
Description
The anti-TREM-1 Abs is against peptidoglycan recognition protein 1 (PGLYRP1). It can be used for bacterial infection and inflammatory diseases.
Antibody Indication
Bacterial Infection; Inflammatory Diseases
