Description
Anti-PDGF-D Antibody, Non-Fucosylated (BioBet-1573ZP) is a Humna monoclonal IgG antibody against PDGF-D. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Kidney Disorder; Liver Disorder; Bone Disorder
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced PDGF-D antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
PDGFD; platelet derived growth factor D; IEGF; SCDGFB; MSTP036; SCDGF-B; platelet-derived growth factor D; PDGF-D; iris-expressed growth factor; spinal cord derived growth factor B; spinal cord-derived growth factor B; spinal cord-derived growth factor-B;
Background
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Alternative Names
platelet derived growth factor D
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with PDGFD include Obstructive Nephropathy and Familiar Ovarian Carcinoma.
Related Pathways
Its related pathways are Phospholipase D signaling pathway and Signaling by GPCR.
Function
Growth factors that play an important role in embryonic development, cell proliferation, cell migration, survival and chemotaxis. A potent mitogen for cells of mesenchymal origin. Play an important role in wound healing. Induces recruitment of macrophages, increases interstitial pressure, and vascular maturation during angiogenesis. It can trigger events leading to mesangial proliferative glomerulonephritis, including the influx of monocytes and macrophages and the production of extracellular matrix (similar).
Post-translational modifications
Activated by proteolytic cleavage. Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator gives rise to the active form.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1573ZP
Description
The antibody bind to zvegf4. The antibody may be polyclonal, monoclonal, murine, humanized or neutralizing. They are useful in the treatment of inter alia, fibroproliferative disorders of the kidney, liver, and bone.
Antibody Indication
Kidney Disorder; Liver Disorder; Bone Disorder
