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Anti-Pan-Ankyrin Pan Fc Silent Antibody (184.1) (CAT#: BioBet-F753P) Datasheet

Product Type
Fc Silent Antibody
Description
The Fc-mediated effector functions of antibodies include antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC), and have been shown to be crucial for the therapeutic efficacy of most clinically approved antibodies. However, engaging immune effectors through FcγR and complement interactions may be detrimental to certain mAb mechanisms of action and so Fc-null or -silenced antibodies may be desired.

Creative Biolabs uses site-directed mutagenesis technology to generate Fc-silenced antibody with reduced effector functions. The mutated Fc domains eliminate the binding of Fc receptors (FcγR, FcR), thereby leading to a significant reduction in ADCC and CDC in comparison to WT IgG.
Immunogen
BALB/c mice were immunised by injection of B. burgdorferi sonicated preparations. Splenocytes were obtained from immunised mice and fused with X63-Ag8 myeloma cells to generate hybridomas.
Species
Bacteria
Cross reactivity
Borrelia burgdorferi
Host
Mouse
Clonality
Monoclonal
Isotype
IgG2b kappa
Clone Number
184.1
Conjugation
Unconjugated
Buffer
PBS only
Application
WB, EL, crystallisation
Storage Instructions
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Target
Pan-Ankyrin Pan
Alternative Names
pan-Ankyrin

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Anti-Pan-Ankyrin Pan Fc Silent Antibody (TP-1) (CAT#: BioBet-F747P)

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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