Description
Anti-PALP Antibody, Non-Fucosylated (BioBet-555ZP) is a mouse monoclonal IgG1 antibody against PALP. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced PALP antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
ALPP
Full Name
alkaline phosphatase, placental
Background
The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells.
Alternative Names
ALPP; alkaline phosphatase, placental; ALP; PALP; PLAP; PLAP-1
Gene ID
250
UniProt ID
P05187
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with ALPP include Hypophosphatasia and Obstructive Jaundice.
Related Pathways
Its related pathways are Intra-Golgi traffic and ATP/ITP metabolism.
Field of research
Cancer antibody; Cell Biology and Cellular Response antibody; Controls and Markers antibody
Post-translational modifications
1.Glycosylation at Asn144 and Asn271 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
BioBet-555ZP
Description
This is a monoclonal antibody having an affinity for tumor cell extracellular ectopic expression PALP and/or IALP antigens, and capable of inhibiting tumor cell growth and metastasis. The monoclonal antibody in the preparation of drugs for treating and preventing digestive tract tumors or digestive tract tumor metastasis.
Antibody Indication
Cancer
