Anti-p28GANK Antibody, Non-Fucosylated (BioBet-1508ZP) (CAT#: BioBet-1508ZP) Datasheet

PSMD10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011]

PSMD10; proteasome (prosome, macropain) 26S subunit, non-ATPase, 10; p28; p28(GANK); dJ889N15.2; 26S proteasome non-ATPase regulatory subunit 10; gankyrin; ankyrin repeat protein; 26S proteasome regulatory subunit p28; hepatocellular carcinoma-associated protein p28-II;

Nucleus

Diseases associated with PSMD10 include Hepatocellular Carcinoma and Dedifferentiated Liposarcoma.

Its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Antigen processing-Cross presentation.

As a chaperone in the assembly of the 26S proteasome, especially the PA700/19S regulatory complex (RC). In the initial steps of the basic sub-complex procedure, assembly is part of the intermediate PSMD10:PSMC4:PSMC5:PAAF1 module, which may be assembled using PSMD5:PSMC2:PSMC1:PSMD2 modules. Independent of the proteasome, it regulates egf-induced AKT activation by inhibiting the RHOA/ROCK/PTEN pathway, resulting in prolonged AKT activation time. Play an important role in ras-induced tumorigenesis. As a proto-oncoprotein, it participates in the negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression can cause phosphorylation of RB1 and degradation of the proteasome. By competing with CDKN2A and CDK4 binding to regulate CDK4-mediated RB1 phosphorylation promotes the binding of MDM2 to p53/TP53, and the effect of MDM2 on p53/TP53 monomer multimerization, suggesting that it has the ability to target the TP53:MDM2 complex to 26S The function of the proteasome. Involved in p53-independent apoptosis. Participate in regulation by keeping nf-kpa-b in the cytoplasm. Combined with the nf-kpa-b component RELA, it accelerates its XPO1/ crm1-mediated nuclear export.

1.Ubiquitination at Lys23, Lys30, Lys90, Lys153, Lys213, and Lys221 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1508ZP

Rabbit

Human

The monoclonal antibody against human p28GANK which correlates to clinical parameters and the significance for poor prognosisis can be used to determine the prognostic assessment of patients with HCC.

Cancer

Cancer