Name: Anti-P-selectin Antibody, Non-Fucosylated (BioBet-1267ZP)
SKU: BioBet-1267ZP
Rating: 5 (1 reviews)

Target

P-selectin

Isotype

IgG

Description

Anti-P-selectin Antibody, Non-Fucosylated (BioBet-1267ZP) is a humanized monoclonal IgG antibody against P-selectin. This product is an ADCC enhanced antibody produced by our Afuco™ platform.

Antibody Indication

Sickle cell disease

Classification

Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced P-selectin antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.

Official Name

SELP

Full Name

selectin P (granule membrane protein 140kDa, antigen CD62)

Background

This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented.

Alternative Names

SELP; selectin P (granule membrane protein 140kDa, antigen CD62); CD62; GRMP; PSEL; CD62P; GMP140; LECAM3; PADGEM; P-selectin; GMP-140; granule membrane protein 140; granulocyte membrane protein; CD62 antigen-like family member P; platelet alpha-granule membrane protein; leukocyte-endothelial cell adhesion molecule 3; platelet activation dependent granule-external membrane protein

Gene ID

6403

Cellular Localization

Plasma membrane

Involvement in Disease

Diseases associated with SELP include Intermittent Claudication and Arteriosclerosis Obliterans.

Related Pathways

Its related pathways are amb2 Integrin signaling and Cell surface interactions at the vascular wall.

Function

Calcium (2+) receptor-dependent myeloid cells bind to neutrophils and monocytes on carbohydrates. Mediates the interaction of activated endothelial cells or platelets with white blood cells. The recognized ligand is sialic acid-Lewis X. The interaction with SELPLG mediates the rapid rolling of white blood cells on the surface of blood vessels at the initial stage of inflammation.

Field of research

Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody

Post-translational modifications

1.Glycosylation at Asn54, Asn98, Asn180, Asn212, Asn219, Asn272, Asn411, Asn460, Asn518, Asn665, Asn716, Asn723, and Asn741 2.Modification sites at PhosphoSitePlus

Biologic Classification

Protein Based Therapies
Monoclonal antibody (mAb)

Antibody Isotype

IgG

Antibody Clone

BioBet-1267ZP

Host

Humanized

Species Reactivity

Human

Description

This is a humanized antibody that binds P-selectin with high affinity and specificity blocks its function, that can be used in the treatment of sickle cell-related pain.

Antibody Indication

Sickle cell disease

Anti-P-selectin Antibody, Non-Fucosylated (BioBet-1267ZP) (CAT#: BioBet-1267ZP) Datasheet

ADCC-Enhanced Antibody

Target

Antibody Specifications

Indication

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