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Anti-OX40 Receptor Antibody, Non-Fucosylated (BioBet-1387ZP) (CAT#: BioBet-1387ZP) Datasheet

Target
OX40 Receptor
Isotype
IgG
Description
Anti-OX40 Receptor Antibody, Non-Fucosylated (BioBet-1387ZP) is a mouse monoclonal IgG antibody against OX40 Receptor. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer; Melanoma
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced OX40 Receptor antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
TNFRSF4
Full Name
tumor necrosis factor receptor superfamily, member 4
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
Alternative Names
TNFRSF4; tumor necrosis factor receptor superfamily, member 4; OX40; ACT35; CD134; IMD16; TXGP1L; tumor necrosis factor receptor superfamily member 4; OX40 antigen; ACT35 antigen; ATC35 antigen; CD134 antigen; OX40 homologue; OX40L receptor; OX40 cell surface antigen; lymphoid activation antigene ACT35; TAX transcriptionally-activated glycoprotein 1 receptor; tax-transcriptionally activated glycoprotein 1 receptor
Gene ID
7293
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with TNFRSF4 include Immunodeficiency 16 and Acute Graft Versus Host Disease.
Related Pathways
Its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and Akt Signaling.
Function
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
Post-translational modifications
Glycosylation at Asn146 and Asn160
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1387ZP
Host
Mouse
Species Reactivity
Human
Description
MEDI6469 is a murine (mouse)-based antibody that binds to and activates a protein in humans called OX40. Because OX40 helps activate the immune system, it is hoped that it will encourage the immune system to recognize and eliminate cancer cells.
Antibody Indication
Cancer; Melanoma

Cancer; Melanoma

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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