Description
Anti-Osteonectin Antibody, Non-Fucosylated (BioBet-1309ZP) is a humanized monoclonal IgG antibody against Osteonectin. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Osteonectin antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
SPARC
Full Name
secreted protein, acidic, cysteine-rich (osteonectin)
Background
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion.
Alternative Names
SPARC; secreted protein, acidic, cysteine-rich (osteonectin); ON; BM-40; osteonectin; cysteine-rich protein; basement-membrane protein 40; secreted protein acidic and rich in cysteine
Gene ID
6678
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with SPARC include Osteogenesis Imperfecta, Type Xvii and Osteogenesis Imperfecta, Type Iv.
Related Pathways
Its related pathways are Degradation of the extracellular matrix and Response to elevated platelet cytosolic Ca2+.
Function
Regulate cell growth through interaction with extracellular matrix and cytokines. Combines calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; low affinity binding to 5-8 Ca(2+) acidic domains and high affinity binding to Ca(2+) ion EF-hand loop.
Field of research
Cancer antibody; Cell Biology and Cellular Response antibody; Controls and Markers antibody; Developmental Biology antibody; Signaling Transduction antibody
Post-translational modifications
1.Glycosylation at Asn116 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1309ZP
Description
The anti-SPARC antibody are used to predict response to melanoma chemotherapy.
Antibody Indication
Cancer
