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Anti-OSCAR Antibody, Non-Fucosylated (CAT#: BioBet-1585ZP) Datasheet

Target
OSCAR
Isotype
IgG
Description
Anti-OSCAR Antibody, Non-Fucosylated (BioBet-1585ZP) is a human monoclonal IgG antibody against OSCAR. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Inflammatory Disease
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced OSCAR antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
OSCAR
Full Name
osteoclast associated, immunoglobulin-like receptor
Background
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Alternative Names
OSCAR; osteoclast associated, immunoglobulin-like receptor; PIGR3; PIgR-3; osteoclast-associated immunoglobulin-like receptor; poly-Ig receptor 3; polymeric immunoglobulin receptor 3; osteoclast associated receptor OSCAR-S1; osteoclast associated receptor OSCAR-S2;
Gene ID
126014
Cellular Localization
Plasma membrane, Extracellular region or secreted
Involvement in Disease
Diseases associated with OSCAR include Mucinous Tubular And Spindle Renal Cell Carcinoma and Decubitus Ulcer.
Related Pathways
Its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.
Function
Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.
Post-translational modifications
Glycosylation at Asn48 and Asn145
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
13F5A5
Host
Human
Species Reactivity
Human
Description
This is antagonistic antibody against OSCAR. It is used for treating an inflammatory disease.
Antibody Indication
Inflammatory Disease

Inflammatory Disease

Related Products

Non-Fucosylated Anti-Human OSCAR (11.1CN5) Therapeutic Antibody (CAT#: BioBet-1586ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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