Description
Anti-Orai1 Antibody, Non-Fucosylated (BioBet-1579ZP) is a human monoclonal IgG antibody against Orai1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Immune Disorder or Disease
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Orai1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
Orai1
Full Name
ORAI calcium release-activated calcium modulator 1
Background
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]
Alternative Names
ORAI1; ORAI calcium release-activated calcium modulator 1; IMD9; TAM2; ORAT1; CRACM1; TMEM142A; calcium release-activated calcium channel protein 1; protein orai-1; transmembrane protein 142A; calcium release-activated calcium modulator 1;
Gene ID
84876
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with ORAI1 include Immunodeficiency 9 and Myopathy, Tubular Aggregate, 2.
Related Pathways
Its related pathways are Platelet homeostasis and Response to elevated platelet cytosolic Ca2+.
Function
Ca (2 +) release-activated Ca (2 +) (firm) channel subunits mediate Ca (2 +) influx and depletion of intracellular calcium (2 +) stores and channel activated Ca (2 +) sensors, STIM1. CRAC channel is the main way for Ca(2+) to flow into t cells. It promotes the body's immune response to pathogens by activating the transcription factor NFAT.
Field of research
Immune System antibody; Signaling Transduction antibody
Post-translational modifications
N-glycosylated. Ubiquitinated. Cys-195 is oxidated, leading to inactivate channel activity.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1579ZP
Description
The antibody specifically binds to human Orai1. We use it in treating immune disorder or disease, such as graft versus host disease (GVHD), rheumatoid arthritis, multiple sclerosis.
Antibody Indication
Immune Disorder or Disease
Immune Disorder or Disease
