Target

Nogo-A

Isotype

IgG

Description

ADCC-Enhanced anti-Nogo-A (GSK 577548) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.

Antibody Indication

Amyotrophic lateral sclerosis

Classification

Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Nogo-A antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.

Official Name

RTN4

Full Name

reticulon 4

Background

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.

Alternative Names

RTN4; reticulon 4; ASY; NSP; NOGO; NOGOC; RTN-X; NOGO-A; NSP-CL; Nogo-B; Nogo-C; RTN4-A; RTN4-C; RTN4-B1; RTN4-B2; NI220/250; Nbla00271; Nbla10545; reticulon-4; foocen; Human NogoA; reticulon 5; My043 protein; neurite outgrowth inhibitor; neurite growth inhibitor 220; neuroendocrine-specific protein C homolog

Gene ID

57142

Cellular Localization

Plasma membrane, Endoplasmic reticulum

Involvement in Disease

Diseases associated with RTN4 include Kleptomania and Temporal Lobe Epilepsy.

Related Pathways

Its related pathways are Neuroscience and Signaling by GPCR.

Function

Induces the formation and stability of endoplasmic reticulum (ER) tubules. They regulate the formation of endoplasmic reticulum membrane by promoting the production of endoplasmic reticulum ducts. They affect the expansion of the nuclear membrane, the formation of nuclear pore complexes and the proper positioning of proteins in the nuclear membrane. However, each isomer has a specific function, mainly depending on their tissue expression specificity (possibly).

Field of research

Neuroscience antibody

Post-translational modifications

N-glycosylated. O-glycosylated. Contains terminal sialic acid groups on its glycan chains.

Biologic Classification

Protein Based Therapies
Monoclonal antibody (mAb)

Antibody Isotype

IgG

Antibody Clone

GSK 577548

Host

Mouse

Species Reactivity

Human

Description

GSK577548 is an anti-nogo-A monoclonal antibody used for treatment of amyotrophic lateral sclerosis. Study show that treatment with anti-Nogo-A antibody improves neuromuscular function in the SOD1(G93A) mouse model of ALS, at least during the earlier stages of disease and suggest that pharmacological inhibition of Nogo-A may be a disease-modifying approach in ALS.

Antibody Indication

Amyotrophic lateral sclerosis

Anti-Nogo-A Antibody, Non-Fucosylated (BioBet-1250ZP) (CAT#: BioBet-1250ZP) Datasheet

ADCC-Enhanced Antibody

Target

Antibody Specifications

Indication

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