Description
Anti-Nogo-66 receptor Antibody, Non-Fucosylated (BioBet-1251ZP) is a mouse monoclonal IgG antibody against Nogo-66 receptor. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Brain Trauma; Spinal Cord Injury; Stroke; Neurodegenerative Diseases; Schizophrenia
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Nogo-66 receptor antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
RTN4R
Full Name
reticulon 4 receptor
Background
This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system.
Alternative Names
RTN4R; reticulon 4 receptor; NGR; NOGOR; reticulon-4 receptor; UNQ330/PRO526; nogo receptor; Nogo-66 receptor
Gene ID
65078
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with RTN4R include Schizophrenia and Leukemia, Acute Lymphoblastic.
Related Pathways
Its related pathways are Guidance Cues and Growth Cone Motility and p75(NTR)-mediated signaling.
Function
RTN4, OMG and MAG receptors. As a receptor for salivated gangliosides GT1b and GM1. In addition, it can also act as a receptor for chondroitin sulfate proteoglycan (similar). Heparin can also be bound (through similarity). The intracellular signal cascade is triggered by the co-receptor NGFR. Signal transduction mediates the activation of Rho and the downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition. It plays a role in regulating axonal regeneration and neuronal plasticity in the adult central nervous system. Play a role in brain development after birth. This is necessary for the normal migration of axons across the midline of the brain and the normal formation of the corpus callosum. Protect motor neurons from apoptosis; inhibition of apoptosis may be mediated through the interaction with MAG. Together with RTN4 and LINGO1, it regulates the movement of neuron precursor cells during cortical development. Like other family members, it plays a role in limiting the number of dendritic spines and synapses formed during brain development.
Field of research
Neuroscience antibody
Post-translational modifications
N-glycosylated. O-glycosylated. Contains terminal sialic acid groups on its glycan chains.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
mAb51
Description
The monoclonal antibody which bind to the Nogo-66 receptor have utility in the treatment of several states including but not limited to mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.
Antibody Indication
Brain Trauma; Spinal Cord Injury; Stroke; Neurodegenerative Diseases; Schizophrenia
Brain Trauma; Spinal Cord Injury; Stroke; Neurodegenerative Diseases; Schizophrenia
