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Anti-Nicastrin Antibody, Non-Fucosylated (BioBet-1557ZP) (CAT#: BioBet-1557ZP) Datasheet

Target
Nicastrin
Isotype
IgG
Description
Anti-Nicastrin Antibody, Non-Fucosylated (BioBet-1557ZP) is a humanized monoclonal IgG antibody against Nicastrin. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Nicastrin antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
NCSTN
Full Name
NCSTN; nicastrin; ATAG1874; anterior pharynx-defective 2;
Background
This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimers disease; however, the nature of the encoded proteins role in Alzheimers disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
Alternative Names
nicastrin
Gene ID
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with NCSTN include Acne Inversa, Familial, 1 and Hidradenitis Suppurativa.
Related Pathways
Its related pathways are Neuroscience and Signaling by GPCR.
Function
It is the basic subunit of the secretase complex, a protease complex that catalyzes the intramembrane cleavage of intact membrane proteins such as Notch receptor and APP (amyloid precursor protein). -Secretase complex plays a role in the regulation of Notch and Wnt signaling cascade and downstream processes by processing key regulatory proteins and regulating the level of CTNNB1 in cells.
Post-translational modifications
N-glycosylated.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1557ZP
Host
Humanized
Species Reactivity
Human
Description
A novel monoclonal antibody A5226A is against the extracellular domain of NCT. A5226A by targeting NCT might be a novel therapeutic strategy against cancer caused by aberrant γ-secretase activity and Notch signaling.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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