Anti-Nicastrin Antibody, Non-Fucosylated (BioBet-1557ZP) (CAT#: BioBet-1557ZP) Datasheet

NCSTN

NCSTN; nicastrin; ATAG1874; anterior pharynx-defective 2;

This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimers disease; however, the nature of the encoded proteins role in Alzheimers disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]

nicastrin

Membrane

Diseases associated with NCSTN include Acne Inversa, Familial, 1 and Hidradenitis Suppurativa.

Its related pathways are Neuroscience and Signaling by GPCR.

It is the basic subunit of the secretase complex, a protease complex that catalyzes the intramembrane cleavage of intact membrane proteins such as Notch receptor and APP (amyloid precursor protein). -Secretase complex plays a role in the regulation of Notch and Wnt signaling cascade and downstream processes by processing key regulatory proteins and regulating the level of CTNNB1 in cells.

N-glycosylated.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1557ZP

Humanized

Human

A novel monoclonal antibody A5226A is against the extracellular domain of NCT. A5226A by targeting NCT might be a novel therapeutic strategy against cancer caused by aberrant γ-secretase activity and Notch signaling.

Cancer

Cancer