Description
The Highly Galactosylated Anti-NGF (Tanezumab), a biobetter antibody contains with a high level of galactosylation.
Antibody Indication
Pain chronic
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced NGF antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
NGF
Full Name
Nerve Growth Factor
Background
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
Alternative Names
Nerve growth factor; nerve growth factor beta polypeptide; NGFB; beta-NGF
Gene ID
4803
UniProt ID
P01138
Cellular Localization
Extracellular region or secreted, Endosome
Genecards
7808
Involvement in Disease
Its related pathways are Neuroscience and NGF Pathway.
Related Pathways
Nerve growth factor is very important for the development and maintenance of the sympathetic and sensory nervous systems. The extracellular ligands of NTRK1 and NGFR receptors activate the cell signaling cascade to regulate the proliferation, differentiation and survival of neurons. Immature NGF precursor (proNGF) acts as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cells that cause RAC1 and/or RAC2 inactivation, actin cytoskeleton reorganization, and neuronal growth cone collapse Signal cascade. Compared to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (similar). Inhibit metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Lysophosphatidylinositol and lysophosphatidylserine bind between the two chains of the homodimer. The lipid-bound form promotes histamine re-enzyme from mast cells, in contrast to the lipid-free form (due to the similarity). 发送反馈 历史记录
Function
Neuroscience antibody; Signaling Transduction antibody
Field of research
1.Glycosylation at Ser43, Thr46, Asn69, and Asn114 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG2
Antibody Clone
Tanezumab
Description
The Highly Galactosylated Anti-NGF (Tanezumab), a biobetter antibody contains with a high level of galactosylation.
Antibody Indication
Pain chronic
