Anti-Neutrophil gelatinase-associated lipocalin Antibody, Non-Fucosylated (CAT#: BioBet-1172ZP) Datasheet

LCN2

lipocalin 2

LCN2; lipocalin 2; 24p3; MSFI; NGAL; neutrophil gelatinase-associated lipocalin; p25; lipocalin-2; oncogene 24p3; siderocalin LCN2; migration-stimulating factor inhibitor; 25 kDa alpha-2-microglobulin-related subunit of MMP-9

Extracellular region or secreted

Diseases associated with LCN2 include Klebsiella Infection and Acute Pyelonephritis.

Its related pathways are Interleukin-4 and 13 signaling and Innate Immune System.

Ferroportin is involved in many processes such as apoptosis, innate immunity and kidney development. By binding to 2,5-dihydroxybenzoic acid (2,5-dhba), iron is combined with iron, which is a siderophore similar in structure to bacterial enterokin, which transfers or removes iron from cells according to different environments. The iron-bound form (holo-24p3) is internalized after binding to the SLC22A17 (24p3R) receptor, resulting in iron release and subsequent increase in intracellular iron concentration. In contrast, the iron-free form (apo-24p3) binds to the SLC22A17 (24p3R) receptor, binds to the iron cells in the cell, chelates iron and transfers iron to the extracellular medium, thereby reducing the intracellular iron concentration. Participate in apoptosis due to the loss of interleukin-3 (IL3): the iron-containing form increases the intracellular iron concentration without promoting apoptosis, and the iron-free form reduces the intracellular iron level, induces the expression of the pro-apoptotic protein BCL2L11/BIM, and causes the cell Apoptosis (similar). Participate in innate immunity; restrict the proliferation of bacteria by isolating iron from the binding of microbial siderophores such as enterokine. It can also be combined with the siderophore of m.b ttuberculosis

Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody; Metabolism antibody; Signaling Transduction antibody

1.Glycosylation at Asn85 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

903

Mouse

Human

The antibody that bind to mammalian NGAL, either alone or in combination have a variety of uses for renal disorders, diseases and injuries, autoimmune diseases, inflammation disease.

Autoimmune Diseases

Autoimmune Diseases