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Anti-Neurturin receptor-A Antibody, Non-Fucosylated (BioBet-920ZP) (CAT#: BioBet-920ZP) Datasheet

Target
Neurturin receptor-A
Isotype
IgG
Description
Anti-Neurturin receptor-A Antibody, Non-Fucosylated (BioBet-920ZP) is a humanized monoclonal IgG antibody against Neurturin receptor-A. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Neurturin receptor-A antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
GFRA2
Full Name
glial fibrillary acidic protein
Background
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative Names
GFRA2; GDNF family receptor alpha 2; NTNRA; RETL2; TRNR2; GDNFRB; NRTNR-ALPHA; GDNF family receptor alpha-2; GDNFR-beta; NTNR-alpha; GFR-alpha 2; RET ligand 2; GDNFR-alpha-2; GDNF receptor beta; neurturin receptor alpha; TRN receptor, GPI-anchored; PI-linked cell-surface accessory protein; TGF-beta-related neurotrophic factor receptor 2; glial cell line derived neurotrophic factor receptor, beta
Gene ID
2675
UniProt ID
Q9UK05
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with GFRA2 include Posterior Pituitary Gland Neoplasm and Malignant Granular Cell Myoblastoma.
Related Pathways
Its related pathways are GDNF-Family Ligands and Receptor Interactions and RET signaling.
Function
neurturin receptor. Mediates the autophosphorylation and activation of RET receptor induced by nrtn. It can also mediate GDNF signaling through the RET tyrosine kinase receptor. [Isoform 2]: Involved in nrtn-induced phosphorylation of "Ser-727" STAT3.
Post-translational modifications
1.Glycosylation at Asn52, Asn357, and Asn413 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-920ZP
Host
Humanized
Species Reactivity
Human
Description
The antibody which bind to NTNRα can be used to treat conditions characterized by unwanted or excessive activation of NTNRα.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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