Description
ADCC-Enhanced anti-Neuropilin-2 (ITAC-B1) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Neuropilin-2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
NRP2
Full Name
neuropilin 2
Background
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Alternative Names
NRP2; neuropilin 2; NP2; NPN2; PRO2714; VEGF165R2; neuropilin-2; neuropilin-2b(0); neuropilin-2a(17); neuropilin-2a(22); receptor for VEGF165 and semaphorins class3; vascular endothelial cell growth factor 165 receptor 2;
Gene ID
8828
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with NRP2 include Wallerian Degeneration and Exudative Vitreoretinopathy 1.
Related Pathways
Its related pathways are Neuroscience and Signaling by GPCR.
Function
High affinity receptors for semaphorin 3C, 3F, VEGF-165, VEGF-145 subtypes of VEGF and PLGF-2 subtypes of PGF. (Microbial infection) As a recipient, human cytomegalovirus five-dependently enters epithelial and endothelial cells.
Post-translational modifications
1.Glycosylation at Asn152, Asn157, Thr595, Thr600, Thr603, Thr607, Asn629, Ser672, and Asn839 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
ITAC-B1
Description
Anti-human neuropilin-2(NRP-2) antibody which recognizes rrNeuropilin-2 extracellular domain can be used for obtaining a medicament intended to increase p53 expression and to induce tumour cell apoptosis in the context of an anticancer treatment.
Antibody Indication
Cancer
