Anti-Neuropeptide Y Antibody, Non-Fucosylated (BioBet-1475ZP) (CAT#: BioBet-1475ZP) Datasheet

NPY

neuropeptide Y

This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

NPY; neuropeptide Y; PYY4; pro-neuropeptide Y; prepro-neuropeptide Y;

Extracellular region or secreted

Diseases associated with NPY include Eating Disorder and Adjustment Disorder.

Its related pathways are Neuroscience and Signaling by GPCR.

NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1475ZP

Human

Human

The proteins comprising antibody variable regions that bind specifically to NPY. This antibody can be used for treating or preventing cancer or anorexia or inducing an immune response.

Cancer; Anorexia

Cancer; Anorexia