Description
Anti-Neuropeptide Y Antibody, Non-Fucosylated (BioBet-1475ZP) is a human monoclonal IgG antibody against Neuropeptide Y. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer; Anorexia
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Neuropeptide Y antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
NPY
Full Name
neuropeptide Y
Background
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
Alternative Names
NPY; neuropeptide Y; PYY4; pro-neuropeptide Y; prepro-neuropeptide Y;
Gene ID
4852
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with NPY include Eating Disorder and Adjustment Disorder.
Related Pathways
Its related pathways are Neuroscience and Signaling by GPCR.
Function
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Post-translational modifications
The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1475ZP
Description
The proteins comprising antibody variable regions that bind specifically to NPY. This antibody can be used for treating or preventing cancer or anorexia or inducing an immune response.
Antibody Indication
Cancer; Anorexia
