Description
Anti-Neurokinin B Antibody, Non-Fucosylated (BioBet-1318ZP) is a human monoclonal IgG antibody against Neurokinin B. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer; Immune System Diseases
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Neurokinin B antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Background
This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded protein is primarily expressed in the central and peripheral nervous system and functions as a neurotransmitter. This protein is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternate splicing results in multiple transcript variants.
Alternative Names
TAC3; tachykinin 3; NKB; HH10; NKNB; PRO1155; ZNEUROK1; tachykinin-3; neurokinin b; neuromedin K; gamma tachykinin 3; preprotachykinin B; preprotachykinin-B
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with TAC3 include Hypogonadotropic Hypogonadism 10 With Or Without Anosmia and Normosmic Congenital Hypogonadotropic Hypogonadism.
Related Pathways
Its related pathways are RET signaling and Signaling by GPCR.
Function
Tachykinin is an active peptide that can stimulate neurons, cause behavioral responses, is a potent vasodilator and secretion promoter, and can (directly or indirectly) contract many smooth muscles (through similarity). It is the key central regulator of gonadal function.
Post-translational modifications
The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1318ZP
Description
The antibody that specifically bind to neurokinin B have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including pre-eclampsia, hypertension, inflammation, asthma, gastrointestinal disorders, anxiety, depression, addiction, or pain.
Antibody Indication
Cancer; Immune System Diseases
