Book a Meeting

Anti-Neublastin Antibody, Non-Fucosylated (PTA-7624) (CAT#: BioBet-583ZP) Datasheet

Target
Neublastin
Isotype
IgG
Description
ADCC-Enhanced anti-Neublastin (PTA-7624) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Neurodegenerative Disease
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Neublastin antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
ARTN
Full Name
artemin
Background
The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative Names
ARTN; artemin; EVN; NBN; ENOVIN; neublastin; neurotrophic factor
Gene ID
9048
UniProt ID
P15514
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with ARTN include Burning Mouth Syndrome and Cerebral Ventricle Cancer.
Related Pathways
Its related pathways are GDNF-Family Ligands and Receptor Interactions and RET signaling.
Function
GFR-alpha-3-RET receptor complex ligand, but can also activate GFR-alpha-1-RET receptor complex. Supports the survival of cultured sensory and sympathetic peripheral neurons, as well as the survival of dopaminergic neurons in the ventral midbrain. It has a strong attracting effect on intestinal hematopoietic cells, thereby promoting the formation of Peyer patchy structure, which is the main component of intestinal-related lymphoid tissue.
Post-translational modifications
1.Glycosylation at Ser60 and Asn202 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
PTA-7624
Host
Humanized
Species Reactivity
Human
Description
Anti-neublastin antibody that are useful in detecting endogenous and/or exogenous neublastin polypeptides and in antagonizing neublastin bioactivity.
Antibody Indication
Neurodegenerative Disease

Neurodegenerative Disease

Related Products

Anti-Neublastin Antibody, Non-Fucosylated (PTA-7625) (CAT#: BioBet-582ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
  • *
USA

UK

Germany

ISO 9001 Certified - Creative Biolabs Quality Management System.