Description
Anti-Nerve growth factor Antibody, Non-Fucosylated (BioBet-1472ZP) is a humanized monoclonal IgG antibody against Nerve growth factor. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Osteoarthritis
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Nerve growth factor antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
NGF
Full Name
Nerve growth factor
Alternative Names
NGF ; Beta-NGF; HSAN5; NGFB
Gene ID
4803
Cellular Localization
Extracellular region or secreted, Endosome
Involvement in Disease
Diseases associated with NGF include Neuropathy, Hereditary Sensory And Autonomic, Type V and Autonomic Neuropathy.
Related Pathways
Its related pathways are Neuroscience and NGF Pathway.
Function
Nerve growth factor is very important for the development and maintenance of the sympathetic and sensory nervous systems. The extracellular ligands of NTRK1 and NGFR receptors activate the cell signaling cascade to regulate the proliferation, differentiation and survival of neurons. Immature NGF precursor (proNGF) acts as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cells that cause RAC1 and/or RAC2 inactivation, actin cytoskeleton reorganization, and neuronal growth cone collapse Signal cascade. Compared to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (similar). Inhibit metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Lysophosphatidylinositol and lysophosphatidylserine bind between the two chains of the homodimer. The lipid-bound form promotes histamine re-enzyme from mast cells, in contrast to the lipid-free form (due to the similarity).
Field of research
Neuroscience antibody; Signaling Transduction antibody
Post-translational modifications
1.Glycosylation at Ser43, Thr46, Asn69, and Asn114 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
PG110
Description
PG110 is a monoclonal antibody that inhibits the effects of the naturally occurring substance, nerve growth factor (NGF). Phase I study to evaluate the safety, tolerability, and pharmacokinetics of PG110 (Anti-NGF Monoclonal Antibody) in patients with pain attributed to osteoarthritis of the knee.
Antibody Indication
Osteoarthritis
