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Creative Biolabs - ADCC+ Antibody

Anti-Nectin-2 Antibody, Non-Fucosylated (Y-414) (CAT#: BioBet-1531ZP) Datasheet

Target
Nectin-2
Isotype
IgG1
Description
ADCC-Enhanced anti-Nectin-2 (Y-414) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Nectin-2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
PVRL2
Full Name
poliovirus receptor-related 2 (herpesvirus entry mediator B)
Background
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Alternative Names
PVRL2; poliovirus receptor-related 2 (herpesvirus entry mediator B); HVEB; PRR2; CD112; PVRR2; nectin-2; poliovirus receptor-like 2; herpesvirus entry protein B;
Gene ID
5819
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with NECTIN2 include Herpes Simplex and Cleft Lip/Palate-Ectodermal Dysplasia Syndrome.
Related Pathways
Its related pathways are Monoamine Transport and Cell junction organization.
Function
T cell signal modulator. It can be a co-stimulator of T cell function or a co-inhibitor, depending on which receptor it binds to. After binding to CD226, it stimulates T cell proliferation and cytokine production, including IL2, IL5, IL10, IL13 and IFNG. By interacting with PVRIG, inhibit the proliferation of t cells. These interactions are competitive. It may be cell adhesion protein. (Microbial infection) The recipients are herpes simplex virus 1 (HHV-1) mutation Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).
Post-translational modifications
1.Glycosylation at Ser95, Asn137, and Asn324 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
Y-414
Host
Rabbit
Species Reactivity
Human
Description
The mAbs are an anti-Nectin-2 Rabbit polyclonal antibody (poAb) and 256 fully human anti-Nectin-2 monoclonal antibody (mAbs), and can be used as targets for antibody therapeutics to treat cancers.
Antibody Indication
Cancer

Cancer

Related Products

Anti-Nectin-2 Antibody, Non-Fucosylated (Y-443) (CAT#: BioBet-1529ZP)
Anti-Nectin-2 Antibody, Non-Fucosylated (Y-055) (CAT#: BioBet-1530ZP)

All products and services are for Research Use Only. Do Not use in humans.

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