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Anti-NAv1.7 Antibody, Non-Fucosylated (BioBet-1263ZP) (CAT#: BioBet-1263ZP) Datasheet

Target
NAv1.7
Isotype
IgG
Description
Anti-NAv1.7 Antibody, Non-Fucosylated (BioBet-1263ZP) is a humanized monoclonal IgG antibody against NAv1.7. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Pain
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced NAv1.7 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
SCN9A
Full Name
sodium channel, voltage gated, type IX alpha subunit
Background
This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder.
Alternative Names
SCN9A; sodium channel, voltage gated, type IX alpha subunit; PN1; ETHA; NENA; SFNP; FEB3B; NE-NA; GEFSP7; HSAN2D; Nav1.7; sodium channel protein type 9 subunit alpha; hNE-Na; peripheral sodium channel 1; neuroendocrine sodium channel; sodium channel protein type IX subunit alpha; voltage-gated sodium channel alpha subunit Nav1.7; voltage-gated sodium channel subunit alpha Nav1.7; sodium channel, voltage-gated, type IX, alpha subunit; sodium channel, voltage-gated, type IX, alpha polypeptide
Gene ID
6335
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with SCN9A include Paroxysmal Extreme Pain Disorder and Indifference To Pain, Congenital, Autosomal Recessive.
Related Pathways
Its related pathways are Neuroscience and Activation of cAMP-Dependent PKA.
Function
Mediates the voltage-dependent sodium ion permeability of the stimulated membrane. Assuming the transmembrane voltage difference of the open or closed conformation, proteins forming sodium-selective Na(+) ions may pass through this channel, according to their electrochemical gradient. It is a subtype of Na(+) channel sensitive to tetragonal toxin. Play a role in the mechanism of pain, especially in the occurrence of inflammatory pain.
Post-translational modifications
Phosphorylation at Ser-1490 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents. Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1263ZP
Host
Humanized
Species Reactivity
Human
Description
This is a monoclonal antibody that targets a NaV1.7 channel voltage sensor, can be used for pain and itch relief.
Antibody Indication
Pain

Pain

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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