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Creative Biolabs - ADCC+ Antibody

Anti-Mucin 17 Antibody, Non-Fucosylated (BioBet-1587ZP) (CAT#: BioBet-1587ZP) Datasheet

Target
Mucin 17
Isotype
IgG
Description
Anti-Mucin 17 Antibody, Non-Fucosylated (BioBet-1587ZP) is a human monoclonal IgG antibody against Mucin 17. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Pancreatic Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Mucin 17 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
MUC17
Full Name
MUC17; mucin 17, cell surface associated; MUC3; mucin-17; MUC-3; MUC-17; membrane mucin MUC17; secreted mucin MUC17; small intestinal mucin-3; small intestinal mucin MUC3;
Background
Membrane mucins, such as MUC17, function in epithelial cells to provide cytoprotection, maintain luminal structure, provide signal transduction, and confer antiadhesive properties upon cancer cells that lose their apical/basal polarization.[supplied by OMIM, Apr 2004]
Alternative Names
mucin 17, cell surface associated
Gene ID
140453
Cellular Localization
Plasma membrane, Extracellular region or secreted
Involvement in Disease
Diseases associated with MUC17 include Biliary Papillomatosis and Tn Polyagglutination Syndrome.
Related Pathways
Its related pathways are Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) and Metabolism of proteins.
Function
Probably plays a role in maintaining homeostasis on mucosal surfaces.
Post-translational modifications
1.Probably cleaved within the SEA domain 2.Modification sites at PhosphoSitePlus 3.N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated 4.Glycosylation at Ser56, Asn471, Asn696, Asn898, Asn1345, Asn2077, Asn2194, Asn3344, Asn4116, Asn4205, Asn4236, Asn4267, Asn4297, and Asn4305
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1587ZP
Host
Human
Species Reactivity
Human
Description
Anti-Muc 17 antibody is an antibody that binds to Mucin17 (Muc17), preferably can be used as an anti-cancer agent for pancreatic cancer.
Antibody Indication
Pancreatic Cancer

Pancreatic Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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