Anti-MSTN Antibody, Highly Galactosylated (BioBet-GA-367ZP) (CAT#: BioBet-GA-367ZP) Datasheet

MSTN

Myostatin

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016]

Myostatin; growth differentiation factor 8; GDF8; GDF-8

Extracellular region or secreted

Its related pathways are PEDF Induced Signaling and Hypertrophy Model.

Acts specifically as a negative regulator of skeletal muscle growth.

1.Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase. 2.Glycosylation at Asn71 3.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1, κ

BioBet-GA-367ZP

Human

Human

The Highly Galactosylated Anti-MSTN (Domagrozumab), a biobetter antibody contains with a high level of galactosylation.

Duchenne muscular dystrophy (DMD)

Duchenne muscular dystrophy (DMD)