Description
Anti-MST1R Antibody, Non-Fucosylated (BioBet-366ZP) is a human monoclonal IgG1, κ antibody against MST1R. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Solid tumors
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced MST1R antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
MST1R
Full Name
Macrophage Stimulating 1 Receptor
Background
This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]
Alternative Names
Narnatumab; 1188275-92-4; IMC-RON8; MST1R; macrophage stimulating 1 receptor (c-met-related tyrosine kinase); PTK8, PTK8 protein tyrosine kinase 8, RON; macrophage-stimulating protein receptor; CD136; CDw136; p185-Ron; MSP receptor; RON variant E2E3
Gene ID
4486
UniProt ID
Q04912
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with MST1R include Nasopharyngeal Carcinoma 3 and Gastroesophageal Adenocarcinoma.
Related Pathways
Its related pathways are Sweet Taste Signaling and Signaling by GPCR.
Function
Receptor tyrosine kinases conduct signals from the extracellular matrix to the cytoplasm by binding to MST1 ligands. Regulate many physiological processes, including cell survival, migration, and differentiation. Ligand binding induces autophosphorylation of RON in its intracellular region on the cell surface, providing a docking site for downstream signal molecules. After the ligand is activated, it interacts with the pi3-kinase subunit PIK3R1, PLCG1 or adaptor GAB1. The recruitment of these downstream effectors by RON leads to the activation of multiple signal cascades, including RAS-ERK, PI3 kinase-akt or PLCgamma-PKC. RON signal activates the wound healing response by promoting epithelial cell migration, proliferation and survival of the wound site. By regulating the migration and phagocytic activity of macrophages, it plays a role in the innate immune response. In addition, RON can also promote signals such as cell migration and proliferation in response to growth factors instead of MST1 ligands. 发送反馈 历史记录
Post-translational modifications
Proteolytic processing yields the two subunits. Autophosphorylated in response to ligand binding on Tyr-1238 and Tyr-1239 in the kinase domain leading to further phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site. Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1, κ
Antibody Clone
BioBet-366ZP
Description
ADCC-enhanced Narnatumab is a non-fucosylated anti-MST1R therapeutic biobetter antibody.
Antibody Indication
Solid tumors
