Description
Anti-MSLN Antibody, Non-Fucosylated (BioBet-365ZP) is a human monoclonal IgG antibody against MSLN. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Solid tumors
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced MSLN antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
MSLN
Full Name
Mesothelin
Background
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Alternative Names
MSLN; mesothelin; CAK1; MPF; CAK1 antigen; megakaryocyte potentiating factor; soluble MPF mesothelin related protein; pre-pro-megakaryocyte-potentiating factor; SMRP;
Gene ID
10232
UniProt ID
Q13421
Cellular Localization
Golgi apparatus, Extracellular region or secreted, Plasma membrane
Involvement in Disease
Diseases associated with MSLN include Mesothelioma, Malignant and Asbestosis.
Related Pathways
Its related pathways are Metabolism of proteins and Adhesion.
Function
Membrane-anchored forms may play a role in cellular adhesion. Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
Field of research
Cancer antibody; Controls and Markers antibody
Post-translational modifications
Both MPF and the cleaved form of mesothelin are N-glycosylated. Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-365ZP
Description
ADCC-enhanced anetumab ravtansine is a non-fucosylated anti-MSLN therapeutic biobetter antibody.
Antibody Indication
Solid tumors
