Anti-MRP3 Antibody, Non-Fucosylated (BioBet-494ZP) (CAT#: BioBet-494ZP) Datasheet

MRP3

Multidrug resistance protein 3

The protein encoded by this gene is a member of the ATP binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extracellular and intracellular membranes. The ABC gene is divided into seven different subfamilies (ABC1, MDR / TAP, MRP, ALD, OABP, GCN20, white). This protein is a member of the MRP subfamily and is involved in multiple drug resistance. The specific function of this protein has not been determined. However, this protein may play a role in the transport of organic anions in bile and intestinal excreta. Alternate splice variants encoding different protein isoforms have been described.

ABCC3 is induced as a hepatoprotective response to various pathological liver conditions. Constitutive androstane receptors, pregnane X receptors and nuclear factor (carotene-derived 2) -like 2 (Nrf2) transcription factors are involved in mediating induction. The functional antioxidant response element in intron 8 of the human ABCC3 gene appears to be responsible for Nrf2-mediated oxidative stress response.

ABCC3, ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2, ATP binding cassette subfamily C member 3

Membrane

Diseases associated with ABCC3 include Dubin-Johnson Syndrome and Extrahepatic Cholestasis.

Its related pathways are Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling and Lamotrigine Pathway, Pharmacokinetics and Pharmacodynamics.

May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).

1.Glycosylation at Asn18, Asn1006, and Asn1007 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-494ZP

Human

Human

An antibody having an antigen binding region capable of binding an epitope located in an extracellular portion of MRP3. antibody targeted at a MRP3 antigen present on cells expressing MRP3 and methods useful in detecting or targeting cells expression the MRP3 antigen, as well as kits, nucleic acids, polypeptides, and cells.

Cancer

Cancer