Description
Anti-MP1 Antibody, Non-Fucosylated (BioBet-1170ZP) is a humanized monoclonal IgG antibody against MP1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Breast Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced MP1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
LAMTOR3
Full Name
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Background
This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13.
Alternative Names
LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; MP1; MAPBP; MAPKSP1; PRO0633; MAP2K1IP1; Ragulator3; ragulator complex protein LAMTOR3; MEK binding partner 1; MAPK scaffold protein 1; mitogen-activated protein kinase scaffold protein 1; late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; mitogen-activated protein kinase kinase 1 interacting protein 1
Gene ID
8649
Cellular Localization
Endosome
Involvement in Disease
Diseases associated with LAMTOR3 include Piebald Trait.
Related Pathways
Its related pathways are RET signaling and Signaling by GPCR.
Function
As part of the ragulator complex, it is involved in amino acid sensing and activation of mTORC1, a signaling complex that promotes cell growth through growth factors, energy levels and amino acids. The small GTPases rag is activated by amino acids through the lysosomal V-ATPase mechanism. Ragulator acts as a guanine nucleotide exchange factor to activate small GTPases rag. Activated ragulator and rag GTPases act as scaffolds to recruit mTORC1 into lysosomes, where mTORC1 is activated. The adaptor protein can enhance the efficiency of mapk2 cascade and promote the activation of mapk2.
Post-translational modifications
1.Ubiquitination at Lys62 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1170ZP
Description
The anti-human Mp1 antibody found to exhibit a high agonistic activity. This shows that the activity of an antibody can be enhanced by making the antibody into a single-chain polypeptide that comprises two or more heavy chain variable regions and two or more light chain variable regions linked via linkers. It can be used for treatment of breast cancer.
Antibody Indication
Breast Cancer
