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Anti-Mouse MBL-A Monoclonal Antibody (clone 8G6) -100 µg (CAT#: CB-P252-AB) Datasheet

Product Type
Antibody
Description
Mannose-binding lectin (MBL), also known as mannose-binding protein (MBP), is a calcium-dependent oligomeric protein that belongs to the collectin family of proteins. It contains a collagen-like domain and a carbohydrate recognition domain , Enabling MBL to recognize carbohydrates (for example, MBL can activate complement pathways that are not related to classical and alternative complement activation pathways by using linked mannose-binding lectin-associated serine protease (MASP-2) in antibodies and C1q-. MASP- 2 Allow C4 and C2 to be cleaved to form C3 convertase. Once bound, MBL exhibits complement-dependent antibacterial activity, such as microbial opsonization and/or microbial lysis through membrane attack complexes, thus innate immunity.
In humans, MBL is encoded by a single gene, while in mice, there are two homologous proteins called MBL-A and MBL-C. The concentration of MBL-A in serum is about 6 times lower than that of MBL-C. In casein and LPS injection models, MBL-A is an acute phase protein, but not MBL-C. In addition, MBL-A-deficient mice have been shown to have abnormal antigen-specific IgM responses and increased sensitivity to infection. Please note that monoclonal antibody 8G6 is a calcium-dependent antibody.
Disease
Infectious diseases
Size
100 µg
Immunogen
Purified mouse MBL-A
Species
Mouse
Host
Rat
Clonality
Monoclonal
Isotype
Rat IgG2a
Clone Number
8G6
Buffer
PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.
Application
Frozen sections, Immuno assays, Immuno fluorescence, Western blot
Application Notes
For immunohistochemistry and western blotting, the diluent that will be used depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution. The typical initial working dilution is 1:50.
Storage Instructions
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Target
MBL-A
Alternative Names
MBL; L-MB; MBL-A; MBP-A; Mbl2

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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