Book a Meeting

Anti-Mouse Factor H Monoclonal Antibody (clone 1A2) -10 mg (CAT#: CB-P517-K) Datasheet

Product Type
Antibody
Description
Monoclonal antibody 1A2 recognizes mouse complement factor H (CFH). CFH is the first regulatory protein of the alternative pathway of the complement system. There are three pathways for complement activation; the classical pathway, the alternative pathway and the lectin activation pathway. These pathways converge to form The C3/C5 convertase that produces C3a, C3b, C5a and C5b has considerable biological activity. Supplementary regulators are necessary to prevent the harmful production of these mediators and potential damage to their own tissues. Cell membrane protein complement receptors 1 (CR1; CD35), decay accelerating factor (CD55) and membrane cofactor protein (CD46) are all members of the complement activation family of regulators. These proteins give C3b and/or C4b to them to accelerate the inherent decay of C3/C5 convertase And/or the ability element factor I (CFI) for the cleavage and inactivation (i) of C3b and C4b as a coenzyme.
Genetic human analysis reveals a clear association between CFH and different human diseases. These diseases include kidney disease, atypical forms of hemolytic-uremic syndrome (aHUS) and membranous proliferative glomerulonephritis (MPGN). Moreover, CFH is associated with age-related macular degeneration (AMD), which is an eye disease.
Disease
Autoimmunity, Nephrology
Size
100 µg
Immunogen
Mouse factor H-human IgG fusion protein
Species
Mouse
Cross reactivity
Rat
Host
Mouse
Clonality
Monoclonal
Isotype
Mouse IgG1
Clone Number
1A2
Buffer
PBS, containing 1% bovine serum albumin and 0.02% sodium azide.
Application
Frozen sections, Immuno assays, Western blot
Application Notes
The diluent used depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution. The typical initial working dilution is 1:50.
Storage Instructions
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Target
Factor H
Alternative Names
CFH, Complement Factor H, Protein beta-1-H

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
  • *
USA

UK