Anti-Mouse C3a Monoclonal Antibody (clone 3/11) -100 µg (CAT#: CB-P245-AB) Datasheet

Product Type
Antibody
Description
Monoclonal antibody 3/11 recognizes C3a, the activating fragment of complement protein C3. C3a is a 190 kDa protein and the highest content of complement protein in serum. C3 is the third part of the complement system and plays a central role in complement activation. The three pathways converge at this key molecule. The cleavage of the key complement component C3 leads to the production of a series of effector molecules with multiple biological functions. The cleavage product C3b promotes the cultivation and subsequent formation of complement. C3a is a small Molecular lysate (approximately 10 kDa), with allergic toxicity and immunomodulatory properties, works through a specific receptor (C3aR), which belongs to the family of G protein-coupled receptors. C3aR- is expressed in a variety of cells , Including bone marrow and non-bone marrow cells, are expressed on hematopoietic stem/progenitor cells. It has been shown that S can promote the transport/homing of these cells to BM. The participation of C3aR on DC and T cells has been shown to upregulate these cells Function.
Monoclonal antibody 3/11 reacts specifically with C3a anaphylactoxin and provides a tool for monitoring acute complement activation (C3a production) in experimental mouse models.
Disease
Infectious diseases
Size
100 µg
Immunogen
Purified mouse C3
Species
Mouse
Host
Rat
Clonality
Monoclonal
Isotype
Rat IgG2a
Clone Number
3/11
Buffer
PBS, and 0.1% bovine serum albumin.
Application
Flow cytometry, Functional studies, Immuno assays, Western blot
Application Notes
For Western blotting (unreduced), diluents will be used, depending on the detection system used. It is recommended that users test reagents and determine their own optimal dilution. The typical initial working dilution is 1:50.
Storage Instructions
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Target
C3a

All products and services are for Research Use Only. Do Not use in humans.

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