Anti-Minichromosome maintenance protein 7 Antibody, Non-Fucosylated (BioBet-1214ZP) (CAT#: BioBet-1214ZP) Datasheet

MCM7

minichromosome maintenance complex component 7

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

MCM7; minichromosome maintenance complex component 7; MCM2; CDC47; P85MCM; P1CDC47; PNAS146; PPP1R104; P1.1-MCM3; DNA replication licensing factor MCM7; CDC47 homolog; homolog of S. cerevisiae Cdc47; minichromosome maintenance deficient 7; protein phosphatase 1, regulatory subunit 104

Nucleus

Diseases associated with MCM7 include Follicular Adenoma and Retinoblastoma.

Its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and E2F mediated regulation of DNA replication.

As a component of the MCM2-7 complex (MCM complex), the MCM complex is a replication helicase necessary for the initiation and extension of DNA replication "once per cell cycle" in eukaryotic cells. The atp enzyme active site in the MCM2-7 loop is formed by the interaction surface of two adjacent subunits, so relative to the atp binding site of the Walker a box of the adjacent subunits, there is a conservative arginine finger The key structure of the base. However, these six atp enzyme active sites may have different contributions to the complex helicase activity. The required s-phase checkpoint activates uv to induce damage.

O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1214ZP

Human

Human

The monoclonal antibody that specifically bind to MCM7 are used for diagnosing high-grade cervical disease comprising detecting overexpression of MCM7, or both MCM6 and MCM7 in a cervical sample from a patient.

Cervical Disease

Cervical Disease