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Anti-Milk fat globule-EGF factor 8 protein Antibody, Non-Fucosylated (BioBet-1220ZP) (CAT#: BioBet-1220ZP) Datasheet

Target
Milk fat globule-EGF factor 8 protein
Isotype
IgG
Description
Anti-Milk fat globule-EGF factor 8 protein Antibody, Non-Fucosylated (BioBet-1220ZP) is a humanized monoclonal IgG antibody against Milk fat globule-EGF factor 8 protein. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Milk fat globule-EGF factor 8 protein antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
MFGE8
Full Name
milk fat globule-EGF factor 8 protein
Alternative Names
MFGE8; milk fat globule-EGF factor 8 protein; BA46; HMFG; MFGM; SED1; hP47; EDIL1; MFG-E8; SPAG10; OAcGD3S; HsT19888; lactadherin; medin; sperm surface protein hP47; sperm associated antigen 10; breast epithelial antigen BA46; O-acetyl disialoganglioside synthase
Gene ID
4240
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with MFGE8 include Anal Paget's Disease and Opisthorchiasis.
Related Pathways
Its related pathways are Metabolism of proteins and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
Function
It plays an important role in maintaining intestinal epithelial homeostasis and promoting mucosal healing. Promote vegf-dependent neovascularization (through similarity). Contribute to the phagocytosis and clearance of apoptotic cells in many tissues. A special ligand for alpha-v/ -3 and alpha-v/ -5 receptors. It also binds to the cell surface rich in phosphatidylserine in a receptor-independent manner. Zona pellucida binding protein may play a role in gamete interaction. Maidin is the main component of amyloid in the aorta.
Field of research
Cell Biology and Cellular Response antibody; Developmental Biology antibody; Microbiology and Infectious Disease antibody
Post-translational modifications
Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1220ZP
Host
Humanized
Species Reactivity
Human
Description
The anti-lactadherin antibody are intended for treatment of tumors including cancer, ophthalmologic disorders and disorders characterized by neo-vascularization.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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