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Anti-MHC class I polypeptide-related sequence B Antibody, Non-Fucosylated (BioBet-1226ZP) (CAT#: BioBet-1226ZP) Datasheet

Target
MHC class I polypeptide-related sequence B
Isotype
IgG
Description
ADCC-Enhanced anti-MHC class I polypeptide-related sequence B (311A7) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced MHC class I polypeptide-related sequence B antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
MICB
Full Name
MHC class I polypeptide-related sequence B
Background
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants.
Alternative Names
MICB; MHC class I polypeptide-related sequence B; PERB11.2; MHC class I mic-B antigen; stress inducible class I homolog; MHC class I chain-related protein B; MHC class I-like molecule PERB11.2-IMX
Gene ID
4277
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with MICB include Dengue Shock Syndrome and Rheumatoid Arthritis.
Related Pathways
Its related pathways are Immune response Role of DAP12 receptors in NK cells and Innate Immune System.
Function
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Post-translational modifications
Proteolytically cleaved and released from the cell surface of tumor cells.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
311A7
Host
Humanized
Species Reactivity
Human
Description
The antibody which bind to MIC and inhibit MIC shedding are used for the treatment of cancer. In humans, the MHC class I chain-related molecule A (MICA) and MICB (generally termed as MIC) are the most investigated NKG2D ligands, which were proposed to play roles in tumor rejection.
Antibody Indication
Cancer

Cancer

Related Products

Anti-MHC class I polypeptide-related sequence B Antibody, Non-Fucosylated (BioBet-1224ZP) (CAT#: BioBet-1224ZP)
Anti-MHC class I polypeptide-related sequence B Antibody, Non-Fucosylated (BioBet-1223ZP) (CAT#: BioBet-1223ZP)
Anti-MHC class I polypeptide-related sequence B Antibody, Non-Fucosylated (BioBet-1225ZP) (CAT#: BioBet-1225ZP)

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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