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Anti-melanotransferrin Antibody, Non-Fucosylated (BioBet-1221ZP) (CAT#: BioBet-1221ZP) Datasheet

Target
melanotransferrin
Isotype
IgG
Description
Anti-melanotransferrin Antibody, Non-Fucosylated (BioBet-1221ZP) is a humanized monoclonal IgG antibody against melanotransferrin. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Melanoma
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced melanotransferrin antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
MFI2
Full Name
antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
Background
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants.
Alternative Names
MFI2; antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5; MTF1; CD228; MAP97; melanotransferrin; membrane-bound transferrin-like protein; melanoma-associated antigen p97, isoform 2
Gene ID
4241
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with MELTF include Osteogenic Sarcoma and Melanotic Neuroectodermal Tumor.
Related Pathways
Its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins.
Function
Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.
Post-translational modifications
1.Glycosylation at Asn38, Asn135, and Asn515 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1221ZP
Host
Humanized
Species Reactivity
Human
Description
The antibody target melanotransferrin, a glycosylphosphatidylinositol-anchored glycoprotein first identified as p97, a cell-surface marker in melanomas.
Antibody Indication
Melanoma

Melanoma

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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