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Anti-Melanocortin-4 receptor Antibody, Non-Fucosylated (CAT#: BioBet-1211ZP) Datasheet

Target
Melanocortin-4 receptor
Isotype
IgG
Description
Anti-Melanocortin-4 receptor Antibody, Non-Fucosylated (BioBet-1211ZP) is a human monoclonal IgG antibody against Melanocortin-4 receptor. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cachexia
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Melanocortin-4 receptor antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
MC4R
Full Name
melanocortin 4 receptor
Background
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity.
Alternative Names
MC4R; melanocortin 4 receptor; melanocortin receptor 4; MC4-R
Gene ID
4160
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with MC4R include Body Mass Index Quantitative Trait Locus 20 and Body Mass Index Quantitative Trait Locus 11.
Related Pathways
Its related pathways are Signaling by GPCR and Peptide ligand-binding receptors.
Function
Corticotropin and alpha-, beta-, and gamma-MSH common heptapeptide core specific receptor. It plays a central role in energy homeostasis and body growth. The receptor is mediated by G protein and stimulates adenylate cyclase (cAMP).
Post-translational modifications
1.Glycosylation at Asn3, Asn17, and Asn26 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1211ZP
Host
Human
Species Reactivity
Human
Description
The autoantibody against the melanocortin-4 receptor (MC4R) which is part of an important pathway regulating energy balance, are used for obese patients.
Antibody Indication
Cachexia

Cachexia

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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