Book a Meeting

Anti-MDL-1 Antibody, Non-Fucosylated (BioBet-726ZP) (CAT#: BioBet-726ZP) Datasheet

Target
MDL-1
Isotype
IgG
Description
Anti-MDL-1 Antibody, Non-Fucosylated (BioBet-726ZP) is a humanized monoclonal IgG antibody against MDL-1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Immune Disorders
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced MDL-1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CLEC5A
Full Name
C-type lectin domain family 5, member A
Background
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined.
Alternative Names
CLEC5A; C-type lectin domain family 5, member A; MDL1; MDL-1; CLECSF5; C-type lectin domain family 5 member A; C-type lectin superfamily member 5; myeloid DAP12-associating lectin 1; myeloid DAP12-associating lectin-1; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5
Gene ID
23601
UniProt ID
Q8WTT0
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with CLEC5A include Dengue Virus and Dengue Shock Syndrome.
Related Pathways
Its related pathways are Innate Immune System and RET signaling.
Function
As an active regulator of osteoclast formation (similar). Cell surface receptors that signal through TYROBP. Regulate inflammation (through similarity). (Microbial infection) Key macrophage receptors of dengue virus serotypes 1-4. Dengue virus binds to CLEC5A and triggers signal transduction through phosphorylation of TYROBP. This interaction does not cause the virus to enter, but stimulates the release of pro-inflammatory cytokines.
Post-translational modifications
1.N-glycosylated. Contains sialic acid residues 2.Glycosylation at Asn32, Asn93, Asn144, and Asn151
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-726ZP
Host
Humanized
Species Reactivity
Human
Description
The antibody specific for myeloid DAP-12 associating lectin (MDL-1) are using in treatment of immune disorders, in particular, infectious diseases and sepsis.
Antibody Indication
Immune Disorders

Immune Disorders

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
  • *
USA

UK

Germany

ISO 9001 Certified - Creative Biolabs Quality Management System.