Book a Meeting

Anti-Matrix metalloproteinase 8 Antibody, Non-Fucosylated (CAT#: BioBet-1236ZP) Datasheet

Target
Matrix metalloproteinase 8
Isotype
IgG
Description
Anti-Matrix metalloproteinase 8 Antibody, Non-Fucosylated (BioBet-1236ZP) is a humanized monoclonal IgG antibody against Matrix metalloproteinase 8. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Inflammatory Diseases
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Matrix metalloproteinase 8 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
MMP8
Full Name
matrix metallopeptidase 8 (neutrophil collagenase)
Background
This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.
Alternative Names
MMP8; matrix metallopeptidase 8 (neutrophil collagenase); HNC; CLG1; MMP-8; PMNL-CL; neutrophil collagenase; collagenase 2; PMNL collagenase; PMN leukocyte collagenase; matrix metalloproteinase-8; matrix metalloproteinase 8 (neutrophil collagenase)
Gene ID
4317
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with MMP8 include Preterm Premature Rupture Of The Membranes and Gingivitis.
Related Pathways
Its related pathways are Degradation of the extracellular matrix and Innate Immune System.
Function
Can degrade fibrillar type I, II, and III collagens.
Post-translational modifications
1.Glycosylation at Asn54, Asn73, Asn112, Asn204, and Asn246 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1236ZP
Host
Humanized
Species Reactivity
Human
Description
The antibody against MMP8 can be used to treat inflammation, such as but not limited to systemic inflammatory response syndrome, sepsis, LPS induced inflammation, and other inflammatory diseases.
Antibody Indication
Inflammatory Diseases

Inflammatory Diseases

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
  • *
USA

UK

Germany

ISO 9001 Certified - Creative Biolabs Quality Management System.