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Anti-Matrix metalloproteinase 14 Antibody, Non-Fucosylated (BioBet-1235ZP) (CAT#: BioBet-1235ZP) Datasheet

Target
Matrix metalloproteinase 14
Isotype
IgG
Description
Anti-Matrix metalloproteinase 14 Antibody, Non-Fucosylated (BioBet-1235ZP) is a human monoclonal IgG antibody against Matrix metalloproteinase 14. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Matrix metalloproteinase 14 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
MMP14
Full Name
matrix metallopeptidase 14 (membrane-inserted)
Background
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
Alternative Names
MMP14; matrix metallopeptidase 14 (membrane-inserted); MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; WNCHRS; MT1-MMP; MT-MMP 1; matrix metalloproteinase-14; membrane type 1 metalloprotease; membrane-type-1 matrix metalloproteinase
Gene ID
4323
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with MMP14 include Winchester Syndrome and Multicentric Osteolysis-Nodulosis-Arthropathy Spectrum.
Related Pathways
Its related pathways are Degradation of the extracellular matrix and Development Endothelin-1/EDNRA signaling.
Function
Endopeptidases that degrade various components of extracellular matrix such as collagen. Activating progliases a is essential for the dissolution and modeling of extracellular collagen in bones and extra-osseous connective tissue during development (through similarity). It may participate in the reorganization of the actin cytoskeleton by cleaving PTK7. By activating MMP15 as a positive regulator of cell growth and migration. Related to pro-MMP2 participates in the formation of fibrovascular tissue. Break down ADGRB1 to release angiostatin-40 which inhibits angiogenesis.
Post-translational modifications
The precursor is cleaved by a furin endopeptidase. Tyrosine phosphorylated by PKDCC/VLK.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1235ZP
Host
Human
Species Reactivity
Human
Description
KD014 is a fully human anti MMP-14 monoclonal antibody used for gastric cancer.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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