Description
Anti-Macrophage mannose receptor 1 Antibody, Non-Fucosylated (BioBet-1241ZP) is a humanized monoclonal IgG antibody against Macrophage mannose receptor 1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Tumors
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Macrophage mannose receptor 1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
MRC1
Full Name
mannose receptor, C type 1
Background
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.
Alternative Names
MRC1; mannose receptor, C type 1; MMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1; macrophage mannose receptor 1; mannose receptor, C type 1-like 1; C-type lectin domain family 13 member D; macrophage mannose receptor 1-like protein 1
Gene ID
4360
Cellular Localization
Plasma membrane, Endosome
Involvement in Disease
Diseases associated with MRC1 include Dengue Virus and Hepatitis B.
Related Pathways
Its related pathways are Tuberculosis and Innate Immune System.
Function
Mediates the endocytosis of macrophage glycoprotein. Can combine sulfuric acid and non-sulfuric acid polysaccharide chains. (Microbial infections) are phagocytic receptors for bacteria, fungi and other pathogens. (Microbial infection) As a receptor for the dengue virus envelope protein e (microbial infection) interacts with the hepatitis B virus envelope protein.
Field of research
Immune System antibody; M1/M2/TAM Marker antibody; Macrophage Marker antibody; M2 Macrophage Marker antibody
Post-translational modifications
1.Glycosylation at Asn104, Asn147, Asn344, Asn529, Asn926, Asn930, Asn1160, and Asn1205 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1241ZP
Description
The immunoglobulin single variable domains directed against human macrophage mannose receptor (MMR) can be used in targeting and in vivo imaging of tumor-associated macrophages, with applications in the field of cancer diagnostics and therapeutics and monitoring of the disease.
Antibody Indication
Tumors
