Target
Macrophage Colony Stimulating Factor 1
Description
Anti-Macrophage Colony Stimulating Factor 1 Antibody, Non-Fucosylated (BioBet-742ZP) is a human monoclonal IgG1k antibody against Macrophage Colony Stimulating Factor 1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Rheumatoid Arthritis; Sarcoidosis; Systemic lupus erythematosus
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Macrophage Colony Stimulating Factor 1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
colony stimulating factor 1 (macrophage)
Background
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants.
Alternative Names
CSF1; colony stimulating factor 1 (macrophage); MCSF; CSF-1; macrophage colony-stimulating factor 1; lanimostim; 9. 14. 4I, 8. 10. 3, PD-360,324, PD-360324
Cellular Localization
Plasma membrane, Extracellular region or secreted
Involvement in Disease
Diseases associated with CSF1 include Pigmented Villonodular Synovitis and Tenosynovial Giant Cell Tumor.
Related Pathways
Its related pathways are Ras signaling pathway and PEDF Induced Signaling.
Function
Hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes, are cytokines that play an important role in survival, proliferation and differentiation. Promote the release of pro-inflammatory chemokines, thus playing an important role in innate immunity and inflammation. It plays an important role in regulating the proliferation and differentiation of osteoclasts and regulating bone resorption, and is necessary for normal bone development. Necessary for normal fertility in men and women. Promote the reorganization of the actin cytoskeleton, regulate the formation of membrane folds, cell adhesion and cell migration. Play a role in lipoprotein clearance.
Field of research
Cell Biology and Cellular Response antibody; Immune System antibody
Post-translational modifications
N- and O-glycosylated. Glycosylation and proteolytic cleavage yield different soluble forms. One high molecular weight soluble form is a proteoglycan containing chondroitin sulfate. O-glycosylated with core 1 or possibly core 8 glycans. Isoform 1 is N- and O-glycosylated. Isoform 3 is only N-glycosylated.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-742ZP
Description
This is a novel neutralizing human monoclonal antibody against monocyte/ macrophage colony stimulating factor (M-CSF). It exhibited a nonlinear PK profile associated with rapid suppression of PD markers and was generally well tolerated. The safety and efficacy profile will be investigated further in a multi-dose study in patients with rheumatoid arthritis.
Antibody Indication
Rheumatoid Arthritis; Sarcoidosis; Systemic lupus erythematosus
