Book a Meeting

Anti-Mac-2-binding protein Antibody, Non-Fucosylated (BioBet-1177ZP) (CAT#: BioBet-1177ZP) Datasheet

Target
Mac-2-binding protein
Isotype
IgG
Description
Anti-Mac-2-binding protein Antibody, Non-Fucosylated (BioBet-1177ZP) is a mouse monoclonal IgG antibody against Mac-2-binding protein. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Lung Cancer (advanced small cell)
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Mac-2-binding protein antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
LGALS3BP
Full Name
lectin, galactoside-binding, soluble, 3 binding protein
Background
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1.
Alternative Names
LGALS3BP; lectin, galactoside-binding, soluble, 3 binding protein; 90K; M2BP; gp90; CyCAP; BTBD17B; MAC-2-BP; TANGO10B; galectin-3-binding protein; MAC2BP; mac-2 BP; L3 antigen; serum protein 90K; Mac-2-binding protein; tumor-associated antigen 90K; basement membrane autoantigen p105; transport and golgi organization 10 homolog B; lectin galactoside-binding soluble 3-binding protein
Gene ID
3959
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with LGALS3BP include Gnathomiasis and Henoch-Schoenlein Purpura.
Related Pathways
Its related pathways are Response to elevated platelet cytosolic Ca2+.
Function
Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
Post-translational modifications
1.Glycosylation at Asn69, Asn125, Asn192, Asn362, Asn398, Ser444, Asn551, and Asn580 2.Modification sites at PhosphoSitePlus 3.Ubiquitination at Lys441 and Lys474
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1177ZP
Host
Mouse
Species Reactivity
Human
Description
The antibody bind Mac-2-binding protein (Mac-2BP), which can be used as a therapeutic target and potential biomarker for lung cancer.
Antibody Indication
Lung Cancer (advanced small cell)

Lung Cancer (advanced small cell)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
USA

UK

Germany

ISO 9001 Certified - Creative Biolabs Quality Management System.